Turning Up the Heat: The Alternative Oxidase Pathway Drives Thermogenesis in Cycad Cones

Adaptive thermogenesis: Turning on the heat

Brown adipocytes play important roles in the regulation of fat storage and body temperature, by virtue of their ability to uncouple mitochondrial fuel oxidation and ATP synthesis. The discovery of a tissue-specific transcriptional coactivator provides new insights into the regulation of thermogenesis by brown adipocytes.

Turning up the heat on tumors

Heat in the Immunoscore is a good predictor of outcomes for patients with colorectal cancer, as a recent review [3] notes. “What that means is, if you are diagnosed with early stage colon cancer that is “hot” and have surgery to remove the primary tumor, your prognosis is good and your cancer will be unlikely to return,” Bender explains. “If it’s cold, your probability of relapsing is much high...

Turning up the heat on acrylamide.

AIDS legislation--turning up the heat?

This paper is not about the medical condition of AIDS. Nor is it about the history of the condition since it was first reported in Atlanta, Georgia in 1981. It looks rather, at the catalogue of legislative and other legal responses to the spread of AIDS. The paper analyses the AIDS condition in its historical context. The hysteria accompanying the outbreak of AIDS is contrasted with the similar...

Turning Up the Heat on Membrane Fluidity

How do cells maintain the fluidity of cellular membrane in response to temperature fluctuation? In this issue of Cell, Ma et al. identify a regulatory circuit involving a heat-induced acyl-CoA dehydrogenase that controls the lipid saturation level and the fluidity of cellular membranes by transcriptionally regulating a lipid desaturase.